The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 16, 2018
Filed:
Feb. 19, 2016
Applicant:
General Electric Company, Schenectady, NY (US);
Inventors:
John Richard Nelson, Clifton Park, NY (US);
Robert Scott Duthie, Schenectady, NY (US);
Gregory Andrew Grossman, Halfmoon, NY (US);
Anuradha Sekher, Belle Mead, NJ (US);
Assignee:
General Electric Company, Schenectady, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2018.01); C12N 9/22 (2006.01); C12Q 1/6858 (2018.01); C07K 14/00 (2006.01); C07K 1/00 (2006.01); C12Q 1/6844 (2018.01); C12Q 1/6806 (2018.01);
U.S. Cl.
CPC ...
C12N 9/22 (2013.01); C07K 1/00 (2013.01); C07K 14/00 (2013.01); C12Q 1/6806 (2013.01); C12Q 1/6844 (2013.01); C12Q 1/6858 (2013.01); C12Y 301/26 (2013.01);
Abstract
Provided herein are mutant endonuclease V enzymes that are capable of nicking an inosine-containing DNA sequence. Nucleic acid assays and agents that employ such mutant endonuclease V enzymes to introduce a nick into a target DNA including one or more inosine, and uses a DNA polymerase to generate amplicons of a target DNA are also described.