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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10081684 B1

PDFFull Text
Date of Patent:
Sep. 25, 2018

Filed:

Jun. 28, 2012

Using sortases to install click chemistry handles for protein ligation

Applicants:

Hidde L. Ploegh, Brookline, MA (US);

Martin D. Witte, Groningen, NL;

Nicholas C. Yoder, Brookline, MA (US);

Inventors:

Hidde L. Ploegh, Brookline, MA (US);

Martin D. Witte, Groningen, NL;

Nicholas C. Yoder, Brookline, MA (US);

Assignee:

Whitehead Institute for Biomedical Research, Cambridge, MA (US);

Attorney:

Wolf, Greenfield & Sacks, P.C.

Primary Examiner:

Julie Ha

Assistant Examiner:

Kristina M Hellman

Int. Cl.
CPC ...
C07K 1/06 (2006.01); C12P 21/04 (2006.01); C07K 16/46 (2006.01); C07K 19/00 (2006.01); C12N 9/00 (2006.01); C12N 9/10 (2006.01); C07K 1/107 (2006.01); C07K 16/18 (2006.01); C12N 9/52 (2006.01); C12N 15/62 (2006.01);
U.S. Cl.
CPC ...
C07K 16/468 (2013.01); C07K 1/107 (2013.01); C07K 1/1072 (2013.01); C07K 16/18 (2013.01); C12N 9/52 (2013.01); C12N 15/62 (2013.01); C07K 2317/31 (2013.01); C07K 2317/569 (2013.01); C07K 2317/62 (2013.01); C07K 2319/00 (2013.01); C07K 2319/21 (2013.01);
Abstract

Methods and reagents for the installation of click chemistry handles on target proteins are provided, as well as modified proteins comprising click chemistry handles. Further, chimeric proteins, for example, bi-specific antibodies, that comprise two proteins conjugated via click chemistry, as well as methods for their generation and use are disclosed herein.

Find Patent Forward Citations

Ploegh, Hidde. (2018). Using sortases to install click chemistry handles for protein ligation (U.S. Patent No. 10081684). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10081684

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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