The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 18, 2018
Filed:
Jul. 30, 2015
Zumutor Biologics, Inc., Woburn, MA (US);
Sohang Chatterjee, Bangalore, IN;
Kavitha Iyer Rodrigues, Bangalore, IN;
Maloy Ghosh, Bangalore, IN;
Sunit Maity, Bangalore, IN;
Rajeshwari Pendse, Bangalore, IN;
Divya Unnikrishnan, Bangalore, IN;
Yogendra Manjunath B. M., Bangalore, IN;
Jahnabi Arika, Bangalore, IN;
Sathyabalan M., Bangalore, IN;
Pavithra M., Kundapur, IN;
Bhargav Prasad, Chennai, IN;
Veeresha K., Bangalore, IN;
Prabhat Kumar Pathak, Varanasi, IN;
Sanghamitra Bhattacharjee, Bangalore, IN;
Pravin Kumar D., Chennai, IN;
Vivek Halan, Tamil Nadu, IN;
Sankaranarayanan Srinivasan, Bangalore, IN;
Anuradha Hora, Sitapur, IN;
Bairavabalakumar N., Chennai, IN;
Karthika Nair, Bangalore, IN;
Aswini Thanigaivel, Chennai, IN;
Amol Maliwalave, Bangalore, IN;
Bharath R. Shenoy, Bangalore, IN;
Anisha Kurup, Delhi, IN;
Zumutor Biologics Inc., San Francisco, CA (US);
Abstract
The present disclosure relates to developing cell lines where specific biological pathways are modified, particularly by modifications in the enzymes of the cell. The present disclosure develops protein expression systems wherein specific modification of glycan chain of the protein is achieved, which produces non-fucosylated proteins, including non-fucosylated antibodies. The non-fucosylated proteins are used in developing therapeutic monoclonal antibodies and biomarkers, and in diagnosis and prognosis of various diseases. The present disclosure employs the Transcription Activator like Effector Nuclease (TALEN) technology for inactivating fucosylation in a cell.