The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 18, 2018
Filed:
Oct. 23, 2013
Applicant:
Kyoto University, Kyoto-shi, Kyoto, JP;
Inventors:
Assignee:
Kyoto University, Kyoto, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/02 (2006.01); C12N 15/63 (2006.01); C07K 14/00 (2006.01); C07H 21/04 (2006.01); C12N 5/074 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0696 (2013.01); C12N 15/63 (2013.01); C12N 2501/16 (2013.01); C12N 2501/405 (2013.01); C12N 2501/60 (2013.01); C12N 2501/602 (2013.01); C12N 2501/603 (2013.01); C12N 2501/604 (2013.01); C12N 2501/606 (2013.01); C12N 2506/00 (2013.01); C12N 2506/1307 (2013.01); C12N 2510/00 (2013.01);
Abstract
The present invention provides a method of improving iPS cell establishment efficiency, comprising contacting a protein involved in primitive streak (PrS) formation, preferably Foxh1, or a nucleic acid that encodes the same with a somatic cell in a nuclear reprogramming step. Also provided is a method of producing an iPS cell, comprising contacting the protein involved in PrS formation or a nucleic acid that encodes the same, and nuclear reprogramming substance(s) with a somatic cell.