The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 18, 2018
Filed:
Sep. 11, 2015
Applicant:
Genentech, Inc., South San Francisco, CA (US);
Inventors:
Sunil Bhakta, San Ramon, CA (US);
Hans Erickson, South San Francisco, CA (US);
Jagath R. Junutula, Fremont, CA (US);
Katherine Kozak, Half Moon Bay, CA (US);
Rachana Ohri, South San Francisco, CA (US);
Thomas Pillow, San Francisco, CA (US);
Assignee:
Genentech, Inc., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/00 (2006.01); C07K 16/32 (2006.01); C07K 16/18 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); A61K 51/10 (2006.01); C07K 16/40 (2006.01); G01N 33/58 (2006.01); A61K 47/68 (2017.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/32 (2013.01); A61K 47/6803 (2017.08); A61K 47/6809 (2017.08); A61K 47/6817 (2017.08); A61K 47/6849 (2017.08); A61K 47/6869 (2017.08); A61K 51/10 (2013.01); C07K 16/00 (2013.01); C07K 16/18 (2013.01); C07K 16/28 (2013.01); C07K 16/2803 (2013.01); C07K 16/3069 (2013.01); C07K 16/3092 (2013.01); C07K 16/40 (2013.01); G01N 33/582 (2013.01); A61K 2039/505 (2013.01); C07K 2317/40 (2013.01); C07K 2317/73 (2013.01); C07K 2317/94 (2013.01);
Abstract
Cysteine engineered antibodies comprising a free cysteine amino acid in the heavy chain or light chain are prepared by mutagenizing a nucleic acid sequence of a parent antibody and replacing one or more amino acid residues by cysteine to encode the cysteine engineered antibody; expressing the cysteine engineered antibody; and isolating the cysteine engineered antibody.