The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 11, 2018
Filed:
Feb. 12, 2015
Applicant:
Merck Patent Gmbh, Darmstadt, DE;
Inventors:
Michael Super, Lexington, MA (US);
Jonathan Davis, Auburndale, MA (US);
Pascal Andre Stein, Boston, MA (US);
Assignee:
Merck Patent GmbH, Darmstadt, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61K 39/40 (2006.01); C07K 16/30 (2006.01); C07K 16/28 (2006.01); C07K 16/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/30 (2013.01); A61K 39/3955 (2013.01); C07K 16/2803 (2013.01); C07K 16/2866 (2013.01); C07K 16/2896 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/41 (2013.01); C07K 2317/56 (2013.01); C07K 2317/567 (2013.01); C07K 2317/732 (2013.01);
Abstract
Anti-CD19 B4 antibodies with modified variable regions are disclosed. The modified anti-CD19 variable region polypeptides have alterations to one or more framework regions or complementarity determining regions of the heavy chain variable region or light chain variable region, thereby to reduce a T-cell response.