The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 11, 2018
Filed:
Feb. 03, 2017
Applicant:
Medimmune, Llc, Gaithersburg, MD (US);
Inventors:
Thomas Linke, Gaithersburg, MD (US);
William K. Wang, Gaithersburg, MD (US);
Ambarish Shah, Gaithersburg, MD (US);
Hasige Sathish, Gaithersburg, MD (US);
Alan Hunter, Gaithersburg, MD (US);
Christopher Thompson, Gaithersburg, MD (US);
Assignee:
MedImmune, LLC, Gaithersburg, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 47/00 (2006.01); A61K 49/00 (2006.01); C07K 16/28 (2006.01); B01D 15/16 (2006.01); B01D 15/36 (2006.01); C07K 1/18 (2006.01); B01J 41/14 (2006.01); B01J 41/20 (2006.01); C07K 17/02 (2006.01); A61K 39/395 (2006.01); A61K 47/02 (2006.01); A61K 47/68 (2017.01);
U.S. Cl.
CPC ...
C07K 16/2851 (2013.01); A61K 39/3955 (2013.01); A61K 47/02 (2013.01); A61K 47/6829 (2017.08); A61K 47/6849 (2017.08); B01D 15/166 (2013.01); B01D 15/363 (2013.01); B01J 41/14 (2013.01); B01J 41/20 (2013.01); C07K 1/18 (2013.01); C07K 16/2803 (2013.01); C07K 17/02 (2013.01); A61K 2039/505 (2013.01); C07K 2317/56 (2013.01); C07K 2317/94 (2013.01); C07K 2319/35 (2013.01); C07K 2319/55 (2013.01);
Abstract
The present invention provides methods for isolating an active polypeptide or immunoconjugate by purification of a solution containing both the active polypeptide or immunoconjugate and an acidic variant thereof, such as a deamidated variant, using anion exchange chromatography. The present invention also provides compositions, formulations, and unit dosage forms comprising the purified polypeptide or immunoconjugate.