The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 04, 2018
Filed:
Jun. 12, 2014
Technical University of Denmark, Kgs. Lyngby, DK;
Niels Bjerg Jensen, Kgs. Lyngby, DK;
Irina Borodina, Kgs. Lyngby, DK;
Yun Chen, Kgs. Lyngby, DK;
Jerome Maury, Kgs. Lyngby, DK;
Kanchana Rueksomtawin Kildegaard, Kgs. Lyngby, DK;
Jochen Förster, Kgs. Lyngby, DK;
Jens Nielsen, Kgs. Lyngby, DK;
TECHNICAL UNIVERSITY OF DENMARK, Kgs. Lyngby, DK;
Abstract
A yeast cell having a reduced level of activity of NAD dependent glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has at least one exogenous gene encoding NADP dependent GAPDH and/or has up-regulation of at least one endogenous gene expressing NADP dependent GAPDH, wherein combined expression of the enzymes NADP dependent GAPDH, PDC, ALD, ACS, ACC* and MCR in said host cell increases metabolic flux towards 3-HP via malonyl-CoA compared to an otherwise similar yeast cell lacking said genetic modification.