The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 04, 2018
Filed:
May. 01, 2007
Arthur Josephus Shaw, Iv, West Lebanon, NH (US);
Sunil G. Desai, Ellicott City, MA (US);
Lee R. Lynd, Meriden, NH (US);
Kara Podkaminer, Hanover, NH (US);
John Bardsley, Cambridge, MA (US);
David Anthony Hogsett, Grantham, NH (US);
Arthur Josephus Shaw, IV, West Lebanon, NH (US);
Sunil G. Desai, Ellicott City, MA (US);
Lee R. Lynd, Meriden, NH (US);
Kara Podkaminer, Hanover, NH (US);
John Bardsley, Cambridge, MA (US);
David Anthony Hogsett, Grantham, NH (US);
THE TRUSTEES OF DARTMOUTH COLLEGE, Hanover, NH (US);
Abstract
Mutant thermophilic organisms that consume a variety of biomass derived substrates are disclosed herein. Strains ofwith acetate kinase and phosphotransacetylase expression eliminated are disclosed herein. Further, strain ALK1 has been engineered by site directed homologous recombination to knockout both acetic acid and lactic acid production. Continuous culture involving a substrate concentration challenge lead to evolution of ALK1, and formation of a more robust strain designated ALK2. The organisms may be utilized for example in thermophilic SSF and SSCF reactions performed at temperatures that are optimal for cellulase activity to produce near theoretical ethanol yields without expressing pyruvate decarboxylase.