The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 04, 2018
Filed:
Jan. 11, 2016
Applicant:
Ohio State Innovation Foundation, Columbus, OH (US);
Inventors:
David Webster Wood, Dublin, OH (US);
Changhua Shi, Tempe, AZ (US);
Assignee:
Ohio State Innovation Foundation, Columbus, OH (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 17/00 (2006.01); C07K 17/08 (2006.01); C12N 9/16 (2006.01); C07K 14/535 (2006.01); C07K 1/22 (2006.01); C07K 14/315 (2006.01);
U.S. Cl.
CPC ...
C07K 17/08 (2013.01); C07K 1/22 (2013.01); C07K 14/3153 (2013.01); C07K 14/535 (2013.01); C12N 9/16 (2013.01); C12Y 304/24029 (2013.01); C07K 2319/00 (2013.01); C07K 2319/21 (2013.01); C12Y 301/03001 (2013.01);
Abstract
Disclosed herein is a protein purification system and methods of using the system. In particular, disclosed is a split intein comprising an N-terminal intein segment, which can be immobilized, and a C-terminal intein segment, which has the property of being self-cleaving, and which can be attached to a protein of interest. Through the self-cleaving mechanism of the intein, the protein of interest can be purified.