The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 28, 2018
Filed:
May. 30, 2013
Qbi Enterprises Ltd., Nes Ziona, IL;
Bio-lab Ltd., Jerusalem, IL;
Sharon Avkin-Nachum, Nes Zionna, IL;
Jean-Christophe Truffert, Saint-Prest, FR;
Myriam Lefoix, Le Bardon, FR;
Jean Hildesheim, Jerusalem, IL;
Tirtsa Kleinman, Jerusalem, IL;
BIO-LAB LTD., Jerusalem, IL;
QBI ENTERPRISES LTD., Nes Ziona, IL;
Abstract
Disclosed herein are double-stranded RNA nucleic acid molecules, which include at least one pyrazolotriazine nucleotide analog and have been modified to exhibit one of the following, increased on-target activity, increased target specificity, enhanced nuclease stability, reduced off target activity and/or reduced immunogenicity when compared to an unmodified or similarly modified dsRNA; pharmaceutical compositions comprising such molecules and methods of use thereof in therapy.