The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 28, 2018
Filed:
Sep. 11, 2017
Thevax Genetics Vaccine Co., Ltd., Taipei, TW;
Chia-Mao Wu, Hsinchu County, TW;
Jiun-Ming Wu, Hsinchu County, TW;
Yi-Chia Lin, Hsinchu County, TW;
Kung-Lung Lee, Hsinchu County, TW;
Chia-Hao Kang, Hsinchu County, TW;
Fu-Hsien Chiang, Hsinchu County, TW;
Cheng-Yung Chang, Hsinchu County, TW;
Wei-Lun Chang, Hsinchu County, TW;
Hsiang-Kai Lin, Hsinchu County, TW;
Chia-Kuan Peng, Hsinchu County, TW;
Wei-Hsiang Lin, Hsinchu County, TW;
Yi-Tsui Chiu, Hsinchu County, TW;
TheVax Genetics Vaccine Co., Ltd., Taipei, TW;
Abstract
A fusion protein for use as a hepatitis B therapeutic vaccine is disclosed. The fusion protein comprises: (a) an antigen-presenting cell (APC)-binding domain or a CD91 receptor-binding domain; (b) a protein transduction domain; and (c) an antigen comprising a hepatitis B virus X protein deletion mutant that lacks amino acids (aa) at least from as 21 to as 50. The protein transduction domain is a fusion polypeptide comprising a T cell sensitizing signal-transducing peptide, a linker, and a translocation peptide. The APC-binding domain or the CD91 receptor-binding domain is located at the N-terminus of the fusion protein, and the antigen is located at the C-terminus of the protein transduction domain.