The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 28, 2018
Filed:
Aug. 31, 2017
Applicant:
Korea University Research and Business Foundation, Seoul, KR;
Inventors:
Je Sang Ko, Seoul, KR;
Jeong-Han Kim, Seoul, KR;
Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/17 (2006.01); C12Q 1/68 (2018.01); G01N 33/50 (2006.01); C12N 5/077 (2010.01); C12Q 1/686 (2018.01);
U.S. Cl.
CPC ...
A61K 38/17 (2013.01); C12N 5/0653 (2013.01); C12Q 1/686 (2013.01); G01N 33/502 (2013.01); C12N 2501/998 (2013.01); C12N 2506/1346 (2013.01); C12N 2506/1353 (2013.01); G01N 2500/00 (2013.01); G01N 2500/10 (2013.01); G01N 2800/042 (2013.01); G01N 2800/044 (2013.01);
Abstract
The present invention relates to a use of a human small leucine zipper protein in the adipocyte differentiation procedure. More specifically, sLZIP binds with PPARγ2 to induce the formation of a complex of HDAC3 and PPARγ2, thereby functioning as a corepressor to negatively inhibit the transcriptional activity of PPARγ2 and suppress the differentiation to adipocytes, and thus can be used as a marker for treating diabetes and obesity and developing new medicines therefor.