The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 14, 2018

Filed:

Jan. 10, 2014
Applicant:

Biocon Limited, Bangalore, IN;

Inventors:

Sanjay Tiwari, Bangalore, IN;

Gourav Awasthi, Pradesh, IN;

Gokul Jothiraman, Nadu, IN;

Arun Chandavarkar, Bangalore, IN;

Assignee:

Biocon Limited, Bangalore, IN;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/81 (2006.01); C12R 1/84 (2006.01); C12N 15/11 (2006.01); C12N 1/16 (2006.01); C07K 14/62 (2006.01); C12P 21/00 (2006.01); C12N 9/48 (2006.01); C12P 1/02 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/62 (2013.01); C12N 1/16 (2013.01); C12N 9/485 (2013.01); C12P 1/02 (2013.01); C12P 21/00 (2013.01); C12Y 304/17002 (2013.01);
Abstract

The present disclosure relates to a comprehensive model for expression of recombinant peptides by. The model uses an easily controllable variable called 'critical nutrient ratio' for obtaining a right balance between product synthesis and it's degradation during the fermentation process. The extra cellular concentration of precursor could be increased by about 10 folds and the degradation constants could be reduced by about 10-20 folds for intracellular and extracellular cases respectively by controlling critical nutrient ratio and addition of soya flour hydrolysate and EDTA.


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