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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10045961 B1

PDFFull Text
Expired
Date of Patent:
Aug. 14, 2018

Filed:

Apr. 10, 2017

Use of sting agonists to treat chronic hepatitis b virus infection

Applicant:

Drexel University, Philadelphia, PA (US);

Inventors:

Jinhong Chang, Chalfont, PA (US);

Fang Guo, Doylestown, PA (US);

Timothy M. Block, Doylestown, PA (US);

Ju-Tao Guo, Lansdale, PA (US);

Assignee:

Drexel University, Philadelphia, PA (US);

Attorneys:

Saul Ewing Arnstein & Lehr LLP

Kathryn Doyle

Domingos J. Silva

Primary Examiner:

Raymond J Henley, Iii

Int. Cl.
CPC ...
A61K 31/35 (2006.01); A61K 31/352 (2006.01); A61K 31/473 (2006.01); G01N 33/50 (2006.01); C12Q 1/70 (2006.01);
U.S. Cl.
CPC ...
A61K 31/352 (2013.01); A61K 31/473 (2013.01); C12Q 1/706 (2013.01); G01N 33/5067 (2013.01); C12Q 2600/136 (2013.01); G01N 2333/02 (2013.01);
Abstract

Provided herein are methods of treating a subject having hepatitis B viral (HBV) infection. More specifically, disclosed herein are methods of stimulating the innate cytokine response in macrophages, dendritic cells and/or liver non-parenchymal cells with small molecular agonists of STING to suppress HBV replication in hepatocytes. The methods are especially suitable for use in the treatment of chronic HBV infections. Also disclosed herein are methods of identifying compounds useful in the treatment of HBV infection.

Find Patent Forward Citations

Chang, Jinhong. (2018). Use of sting agonists to treat chronic hepatitis b virus infection (U.S. Patent No. 10045961). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10045961

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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