The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 31, 2018
Filed:
Mar. 23, 2016
Applicant:
Massachusetts Institute of Technology, Cambridge, MA (US);
Inventors:
Shuguang Zhang, Lexington, MA (US);
Alexander Rich, Cambridge, MA (US);
Karolina Corin, Cambridge, MA (US);
Lotta Tolstoy Tegler, Linkoping, SE;
Assignee:
Massachusetts Institute of Technology, Cambridge, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/705 (2006.01); C07K 14/715 (2006.01); G01N 33/68 (2006.01); A61K 38/17 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/705 (2013.01); A61K 38/17 (2013.01); A61K 38/177 (2013.01); A61K 38/1793 (2013.01); C07K 14/7158 (2013.01); G01N 33/6863 (2013.01); A61K 38/00 (2013.01);
Abstract
The present invention is directed to a method of preparing a water-soluble variant of a G-protein coupled receptor (GPCR), the method comprising replacing residues leucine (L), isoleucine (I), valine (V), and phenylalanine (F) in hydrophilic surface α-helical positions b, c, and f but not positions a, d, e, and g within the-transmembrane α-helical domain of the GPCR with glutamine (Q), threonine (T), threonine (T), and tyrosine (Y), respectively.