The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 31, 2018
Filed:
Jan. 20, 2017
Applicant:
The United States of America, As Represented BY the Secretary, Dept. of Health and Human Services, Washington, DC (US);
Inventors:
Donald P. Bottaro, Rockville, MD (US);
Fabiola Cecchi, Rockville, MD (US);
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/18 (2006.01); C07K 14/475 (2006.01); C12N 5/10 (2006.01); C12N 1/21 (2006.01); C12N 15/63 (2006.01); C07K 14/52 (2006.01); C07K 14/71 (2006.01);
U.S. Cl.
CPC ...
C07K 14/475 (2013.01); A61K 38/1866 (2013.01); C07K 14/52 (2013.01); C07K 14/71 (2013.01);
Abstract
The present invention provides variant VEGF polypeptides which have been altered in their C-terminal heparin binding region to lower their heparin binding affinity. These variants have been found to act as receptor antagonists for VEGF receptors and antagonize angiogenesis. These variants are useful to treat diseases characterized by pathological angiogenesis.