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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10022324 B1

PDFFull Text
Date of Patent:
Jul. 17, 2018

Filed:

Oct. 15, 2014

Polysialic acid-polycaprolactone micelles for drug delivery

Applicant:

Rebecca Bader, Billerica, MA (US);

Inventor:

Rebecca Bader, Billerica, MA (US);

Assignee:

Syracuse University, Syracuse, NY (US);

Attorneys:

Bond Schoeneck & King, PLLC

George McGuire

Primary Examiner:

Lezah Roberts

Int. Cl.
CPC ...
A61K 9/107 (2006.01); A61K 31/366 (2006.01); A61K 31/573 (2006.01); A61K 31/728 (2006.01); A61K 38/13 (2006.01); A61K 47/34 (2017.01); A61K 47/36 (2006.01); A61K 31/726 (2006.01); A61K 9/00 (2006.01); A61K 9/19 (2006.01);
U.S. Cl.
CPC ...
A61K 9/1075 (2013.01); A61K 9/0019 (2013.01); A61K 9/19 (2013.01); A61K 31/366 (2013.01); A61K 31/573 (2013.01); A61K 31/726 (2013.01); A61K 31/728 (2013.01); A61K 38/13 (2013.01); A61K 47/34 (2013.01); A61K 47/36 (2013.01);
Abstract

PSA-PCL micelles were developed as carrier systems for pharmaceutical drugs. As an example, cyclosporine A (CyA) was encapsulated in the micelles and physical characterization, including size and zeta potential, demonstrated that the micelles possess favorable properties for drug delivery. In vitro studies verified that rheumatoid arthritis synovial fibroblasts are able to internalize the CyA-loaded micelles. CyA was released from the PSA-PCL micelle upon uptake and subsequently, partitioned into the phospholipid membrane. The PSA-PCL micelles also demonstrated improved therapeutic efficacy in drug delivery when used to deliver statins and disease modifying anti-rheumatic drugs (DMARDs).

Find Patent Forward Citations

Bader, Rebecca. (2018). Polysialic acid-polycaprolactone micelles for drug delivery (U.S. Patent No. 10022324). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10022324

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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