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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10017784 B1

PDFFull Text
Date of Patent:
Jul. 10, 2018

Filed:

Nov. 17, 2014

Gene transfer into airway epithelial stem cell by using lentiviral vector pseudotyped with rna virus or dna virus spike protein

Applicant:

Dnavec Corporation, Ibaraki, JP;

Inventors:

Katsuyuki Mitomo, Ibaraki, JP;

Makoto Inoue, Ibaraki, JP;

Hitoshi Iwasaki, Ibaraki, JP;

Mamoru Hasegawa, Ibaraki, JP;

Eric W. Alton, London, GB;

Uta Griesenbach, London, GB;

Assignee:

ID PHARMA CO., LTD., Tsukuba, JP;

Attorney:

Seed IP Law Group LLP

Primary Examiner:

Maria Marvich

Int. Cl.
CPC ...
A61K 48/00 (2006.01); C12N 15/867 (2006.01); C12N 15/10 (2006.01); A61K 39/21 (2006.01); C12N 15/11 (2006.01); C12N 15/45 (2006.01); C12N 15/86 (2006.01); A61K 38/17 (2006.01); C07K 14/47 (2006.01); C12N 5/071 (2010.01); A61K 9/00 (2006.01); A61K 38/16 (2006.01); C12N 7/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); A61K 9/0043 (2013.01); A61K 38/162 (2013.01); A61K 38/177 (2013.01); A61K 38/1709 (2013.01); C07K 14/4712 (2013.01); C12N 5/0688 (2013.01); C12N 7/00 (2013.01); A61K 48/00 (2013.01); C12N 2510/00 (2013.01); C12N 2740/15033 (2013.01); C12N 2740/15043 (2013.01); C12N 2740/15045 (2013.01); C12N 2810/609 (2013.01); C12N 2810/6072 (2013.01);
Abstract

The present inventors successfully introduced genes into stem cells of airway epithelial tissues using simian immunodeficiency virus vectors pseudotyped with F and HN, which are envelope glycoproteins of Sendai virus. Gene transfer into airway epithelial tissue stem cells using a vector of the present invention is useful for gene therapy of genetic respiratory diseases such as cystic fibrosis. Furthermore, it is possible to select respiratory organs such as the lungs as production tissues for providing proteins that are deficient due to genetic diseases.

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