The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 26, 2018
Filed:
Mar. 14, 2014
Applicant:
University of Massachusetts, Boston, MA (US);
Inventors:
Jeanne B. Lawrence, Mapleville, RI (US);
Jun Jiang, Shrewsbury, MA (US);
Lisa L. Hall, Framingham, MA (US);
Assignee:
University of Massachusetts, Boston, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); C12N 15/63 (2006.01); A61K 35/28 (2015.01); A01K 67/027 (2006.01); C12N 9/12 (2006.01); C12N 15/85 (2006.01); C12N 15/90 (2006.01); C12N 15/11 (2006.01); A61K 48/00 (2006.01); A61K 35/12 (2015.01);
U.S. Cl.
CPC ...
A61K 35/28 (2013.01); A01K 67/0271 (2013.01); A01K 67/0275 (2013.01); C12N 9/12 (2013.01); C12N 15/111 (2013.01); C12N 15/1137 (2013.01); C12N 15/85 (2013.01); C12N 15/8509 (2013.01); C12N 15/907 (2013.01); C12Y 207/12001 (2013.01); A01K 2207/12 (2013.01); A01K 2217/072 (2013.01); A01K 2217/15 (2013.01); A01K 2217/203 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0318 (2013.01); A01K 2267/0356 (2013.01); A61K 48/005 (2013.01); A61K 48/0075 (2013.01); A61K 2035/124 (2013.01); C12N 2310/111 (2013.01); C12N 2310/113 (2013.01); C12N 2310/14 (2013.01); C12N 2330/51 (2013.01); C12N 2800/40 (2013.01); C12N 2810/10 (2013.01); C12N 2830/003 (2013.01); C12N 2830/32 (2013.01); C12N 2999/005 (2013.01);
Abstract
Methods and compositions for reducing expression of genes on Chromosome 21 ('Chr 21') by targeting an XIST transgene to the Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) gene or a Regulator of calcineurin 1 (RCAN1) gene, and cells and transgenic animals comprising an XIST transgene inserted into a DYRK1A or RCAN1 allele, e.g., cells and animals trisomic for human Chr 21 and mouse Chr 16.