The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 19, 2018
Filed:
Apr. 21, 2016
Consejo Nacional DE Investigaciones Científicas Y Técnicas, Buenos Aires, AR;
Fundación Sales, Buenos Aires, AR;
Inis Biotech Llc, Milford, DE (US);
Gabriel Adrián Rabinovich, Buenos Aires, AR;
Santiago Di Lella, Berlin, DE;
Dario Ariel Estrin, Buenos Aires, AR;
Julio Javier Carmelo, Buenos Aires, AR;
Santiago Patricio Mendez Huergo, Caba CP, AR;
Consejo Nacional de Investigaciones Cientificas Y Técnicas, Buenos Aires, AR;
Fundación Sales, Buenos Aires, AR;
INIS Biotech LLC, Milford, DE (US);
Abstract
Galectin-1 polypeptide variants that include a mutation of the histidine residue corresponding to position 52 of the full-length amino acid sequence of native human Gal-1 as shown in SEQ ID NO: 1, the mutation being a substitution of the histidine to tyrosine or asparagine, providing resistance to acidosis otherwise resulting in deactivation of the native human Gal-1. The Galectin-1 polypeptide variants may include one or more additional mutation(s) of the cysteine residue corresponding to a position selected from 2, 16, 88, or combinations thereof of the full-length amino acid sequence of native human Gal-1 as shown in SEQ ID NO: 1, the additional mutation being a substitution of the cysteine to serine, and providing resistance to oxidation.