Ajinomoto Co., Ltd.

Yutaka Ishiwatari

Yuzuru Eto

Takami Maekawa

Seiji Kitajima

Yuko Kai

A sweet taste substance or a sweet taste-regulating substance is detected by contacting a test substance with a cell that expresses a chimeric protein of human T1R2 and mouse T1R2, and/or a chimeric protein of human T1R3 and mouse T1R3, and may further express a G protein &#x3b1; subunit, and by detecting an interaction between the chimeric proteins and the test substance.

Sweet taste receptor chimeric proteins and use thereof

By contacting a test substance with a cell that expresses a Kv3.2 protein, and comparing observed cation influx into the cell with cation influx into the cell observed when the test substance is not contacted with the cell, a salty taste modulating substance such as salt alternative compound, or salt perception enhancing or inhibiting compound is screened.

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Kanagawa, Japan

Yutaka Ishiwatari