Leland Stanford Junior University

The Texas A&m University System

Yunfeng Cheng

Jianghong Rao

Jeffrey D Cirillo

Hexin Xie

Zixin Chen

Jianghang Xie

Jinghang Xie

Min Chen

Embodiments of the synthesis, radiolabeling and biological applications of an activatable tracer that undergoes intramolecular cyclization and aggregation upon activation by cleavage of a blocking moiety are provided. The probes of the disclosure allow for target-controlled self-assembly of small molecules in living subjects for imaging and drug delivery. The aggregated nanoprobes of the disclosure may be detectable optically, by PET detection, magnetic resonance imaging, and the like depending on the detectable reporter attached to the nanoprobe.

Caspase-3-triggered molecular self-assembling PET probes and uses thereof

The compositions of the present disclosure provide novel fluorogenic probes for use in the specific imaging and detection of mycobacteria species, and in particular &#x3b2;-lactam-antibiotic resistant. Specificity for mycobacteria is conferred on these probes by incorporating a moiety that specifically targets the unique trapping mechanism of the DprE1 found in in mycobacteria. Accordingly, only Mycobacteria species that express both a &#x3b2;-lactamase and DprE1 enable both the activation of the caged fluorescent probe, and the affixing of the released fluorescent probes to the bacteria cells through the functioning reduction-covalent binding mechanism. Advantageously, such a probe is able, at its most sensitive, to allow singledetection.

Probes for rapid and specific detection of mycobacteria

&#x3b2;-Lactamase substrates and methods for using the substrates to detect &#x3b2;-lactamase and to diagnose tuberculosis.

2,7-disubstituted cephalosporin derivatives as &#x3b2;-lactamase substrates and methods for their use for the diagnosis of tuberculosis

2,7-disubstituted cephalosporin derivatives as beta-lactamase substrates and methods for their use for the diagnosis of tuberculosis

Growing community of inventors

Palo Alto, CA, United States of America

Yunfeng Cheng