Kyowa Hakko Kogyo Co., Ltd.

Yoshiyuki Yamada

Masaji Kasai

Shinji Tomioka

Kazumi Amatsu

Shoichi Mizutaki

Yukiteru Mimura

Yutaka Osawa

Hiroyuki Shinmura

Yasunori Nakaguchi

Kunimi Inoue

Yasuyuki Ono

Yoshikazu Mori

N-chloroacetylglutamine is produced by reacting chloroacetyl chloride with an alkaline aqueous solution of glutamine the presence of a water-immiscible organic solvent, separating an aqueous layer by liquid-liquid separation, and crystallizing N-chloroacetyl-glutamine from the aqueous layer under acidic conditions. N-Chloroacetyl-glutamine useful as an intermediate for producing glycyl-L-glutamine which has higher stability than L-glutamine and is used as a component of an infusion solution can be obtained with high efficiency at low cost.

Process for producing glutamine derivative

Disclosed is a process for producing alanylglutamine, which comprises reacting an N-(2-substituted)-propionylglutamine compound represented by the formula (I): ##STR1## where X represents halogen, alkylsulfonyloxy, or substituted or unsubstituted arylsulfonyloxy, with ammonia at a temperature of 60.degree. C. or below. in accordance with the present invention, highly purified alanylglutamine can be produced in a high yield, without racemization.

Process for producing alanylglutamine

Disclosed is a process for producing alanylglutamine, which comprises reacting an N-(2-substituted)-propionylglutamine compound represented by the formula (I): ##STR1## where X represents halogen, alkylsulfonyloxy, or substituted or unsubstituted arylsulfonyloxy, with ammonia at a temperature of 60.degree. C. or below. In accordance with the present invention, highly purified alanylglutamine can be produced in a high yield, without racemization.

Process for producing alanylgutamine

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Sakai, Japan

Yoshiyuki Yamada