Nippon Kayaku Kabushiki Kaisha

Takara Shuzo Co., Inc.

Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai

Takara Bio Inc.

Takara Shuzo Kabushiki Kaisha

Takara Shuzo Col., Ltd.

Takaru Shuzo Co., Ltd.

Yoshihisa Umeda

Ikunoshin Kato

Tetsushi Saino

Hamao Umezawa

Tomio Takeuchi

Katsushige Ikai

Teruya Nakamura

Tsugio Tomiyoshi

Makoto Moriguchi

Katsutoshi Takahashi

Rinzo Nishizawa

Kyuichi Nemoto

Takaaki Ohkuma

Hiroshi Kihara

Hironobu Hiraga

Akio Fujii

Toru Kurome

Takeji Sakasai

Takako Mae

Tetushi Saino

Keiko Miyazaki

Keiko Watanabe

Food or beverage where fucoidan which is derived from a fucoidan-containing substance is contained therein, added thereto and/or diluted therein. Food or beverage where fucoidan which is derived from a fucoidan-containing substance and where algins are reduced or eliminated, is contained therein. Apoptosis-inducing food or beverage where an effective amount of fucoidan having an apoptosis-inducing ability is contained therein.

Food or beverage containing fucoidan and method of production thereof

Food or beverage additive containing fucoidan and food and beverage containing fucoidan

The invention provides crystalline deoxyspergualin trihydrochloride, a process for the preparation of the same and a suppository composition containing the same. The compound and composition has antitumor and immunosuppressing activity.

Crystalline deoxyspergualin, process for its preparation and suppository

The invention provides crystalline deoxyspergualin trihydrochloride, a process for the preparation of the same and a suppository composition containing the same. The compound and composition has antitumor and immunosuppressive activity.

Novel spergualin-related compounds represented by the general formula (I): ##STR1## wherein X represents --(CH.sub.2).sub.1-5 -- or a phenylene group which may be substituted; m represents 0, 1 or 2; n represents 1 or 2; and R.sub.1 represents --(CH.sub.2).sub.1-3 --COOH, and pharmacologically acceptable salts thereof, possess an immunopotentiating activity, and are expected to be useful as immunopotentiators applicable to warm blooded animals.

Spergualin-related compound and use thereof

The present invention relates to novel spergualin-related compounds represented by the general formula [I]: ##STR1## wherein X is --(CH.sub.2).sub.1.about.5 or ##STR2## Y is a hydrogen atom or a residue obtained by removing a hydroxyl group from the carboxyl group of an amino acid or a peptide; m is 0, 1 or 2 and n is 1 or 2, with the proviso that Y is not a hydrogen atom when n is 2 and m is 0. This compounds are stable and exhibit a high immunosuppressive activity.

Novel spergualin-related compounds and compositions

The present invention provides a use for the preparation of an immunopotentiator of a spergualin-related compound represented by the following general formula [I] or a pharmacologically acceptable salt thereof: ##STR1## wherein X represents ##STR2## or --(CH.sub.2).sub.n --, Y represents a hydrogen atom or a hydroxyl or hydroxymethyl group,

Immunopotentiator and spergualin-related compound therefor

Process for purifying spergualin-related compounds and their synthetic intermediates, by subjecting a solution containing such spergualin-related compounds or intermediates to electrodialysis and/or reverse osmosis.

Process for the purification of spergualin-related compounds

Glyoxylylspermidine, an intermediate for 15-deoxyspergualin-related compounds, is prepared in an oxidative cleavage reaction.

Method for producing glyoxylylspermidine and the use thereof for the

The invention relates to Spergualin-related compounds of the formula: ##STR1## (wherein R.sub.1 is a lower alkylene group which may be substituted by a hydroxymethyl group; X is a hydrogen atom or a halogen atom; m and n are each 0 or an integer of 1 to 5) and salts thereof and a process for producing the same.

Spergualin-related compounds having a phenylene group as well as a

This invention relates to a novel spergualin-related compound and a process for the production thereof. The novel compound, which has a high antitumor activity, is represented by the general formula ##STR1## wherein R.sub.1 represents a hydrogen atom, hydroxyl group, or an aliphatic acyloxy group having 1 to 10 carbon atoms, R.sub.2 represents an amino acid residue (except for the residue of .alpha.-hydroxyglycine) formed by removing one hydrogen atom and hydroxyl group from respectively the .alpha.- or .omega.-amino group and the .alpha.-carboxyl group of an .alpha.- or .omega.-amino acid, said amino acid residue forming acid amide linkages with the adjacent carbonyl group and amino group, and m is an integer of 4 to 6.

Growing community of inventors

Otsu, Japan

Yoshihisa Umeda