Academia Sinica

Cellmax, Ltd

Ying-Chih Chang

Han-Chung Wu

Huangpin Ben Hsieh

Jen-Chia Wu

Jr-Ming Lai

Po-Yuan Tseng

Chia-Hsien S Hsu

Hung-Jen Shao

Huai-Lu Chen

Si-Hong Lu

Tsung-Fu Hung

This invention relates to a surface coating for capture circulating rare cells, comprising a nonfouling composition to prevent the binding of non-specific cells and adsorption of serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the nonfouling and bioactive compositions. The invention also provide a surface coating for capture and purification of a biological substance, comprising a releasable composition to release the non-specific cells and other serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the releasable and bioactive compositions. The present invention also discloses a novel microfluidic chip, with specific patterned microstructures to create a flow disturbance and increase the capture rate of the biological substance.

Capture, purification, and release of biological substances using a surface coating

The present disclosure provides a substrate for cell culture. Systems comprising the substrate, and methods for using and manufacturing the substrate are also disclosed herein.

Cell culture substrates, methods and uses thereof

The disclosure provides for compositions and methods of making and using a foam composition and its utility in clinical applications.

Methods and systems for cancer diagnosis and prognosis

The disclosure provides for compositions and methods for the collection of rare cells using an interspersed microstructure design.

Collector architecture layout design

A system and method thereof for collecting and concentrating a biologic substance of interest is provided. The biologic of interest obtained from a biologic sample present at an initial low concentration (or low number counts) can be captured and released through a collection device of the system to an intermediate second concentration, and further recovered through a concentration device of the system to a third concentration, thereby facilitating subsequent detection, characterization, enumeration, immunostaining, inspection, imaging, culturing, molecular analysis, and/or other assays.

Growing community of inventors

Taipei, Taiwan

Ying-Chih Chang