University of Southern California

Cedars-sinai Medical Center

Da Zen Theranostics, Inc.

Nupro Corporation

Yi Zhang

Mark Salman Humayun

Mark Edward Thompson

Chongwu Zhou

Frank N Chang

Leland W K Chung

George Paul Tuszynski

John J Whalen, Iii

Niki Bayat

Ruoxiang Wang

Gina Chia Yi Chu

Stefan Mrdenovic

Jian Zhang

Liyuan Yin

Qinghua Zhou

Aldo Oregon

Paulo Falabella

Lewis Gomez De Arco

Yong Yue

Gang Wang

Luyao Zhang

Gina Chi-Yi Chu

Gina Chia-Yi Chu

The present invention generally relates to sensitizer compounds and their use to sensitize cancer and/or pre-cancerous cells of certain cancers to treatment with certain resistance-prone therapeutics used in cancer therapy. In embodiments, the conjugates of particular esters or amides of Near Infrared Dyes, are used as sensitizers to avoid or overcome therapeutic resistance once formed. In embodiments, the sensitizers include conjugates with Cisplatin, Simvastatin, Artemisinin, platin-based compounds or statins. In embodiments, the resistance prone cancer therapeutics include cisplatin, gemcitabine, doxorubicin, paclitaxel, docetaxel, and platin-based compounds. These may be administered in combination with the sensitizer, or the sensitizer itself may comprise an therapeutic-derived moiety conjugated to the sensitizer, for example as is the case for dye-CIS conjugated sensitizers. Alternatively, the sensitizer may be co-administered with one or more therapeutic. Embodiments of the invention may advantageously be used in cancers that have a tendency to develop resistance to such cancer therapeutics and/or to form metastases, including e.g. lung, pancreatic, prostate, testicular, ovarian, cervical, bladder, breast, head and neck, esophageal, and stomach, cancers, germ cell tumors, lymphomas and other cancers.

Compounds and methods to sensitize cancer cells to cisplatin

The present invention generally relates to sensitizer compounds and their use in combination with Tyrosine Kinase Inhibitors (TKIs) for sensitizing tumor, cancer or pre-cancerous cells to TKI treatment. In particular, the present invention relates to administration regimes that combine TKIs such as Gefitinib or Icotinib with TKI-sensitizing DZ1 esters and amides conjugated to statin or platin-based drugs, or to Artemisinin, including, without limitation: DZ1-Simvastatin amide, DZ1-Simvastatin ester, DZ1-Cisplatin ester, and DZ1-Cisplatin amide, DZ1-Artemisinin ester, and DZ1-Artemisinin amide. Furthermore, the present invention relates to improved TKI treatment of cancers by sensitizing tumor, cancer or pre-cancerous cells, in particular cancers that develop TKI resistance, including e.g. lung cancer and pancreatic cancer.

Compounds and methods to sensitize cancer cells to tyrosine kinase inhibitors

Described herein is a peptide, a multimodal peptide ligand imaging agent and methods for use in tumor targeting, tumor visualization, drug delivery and as an imaging ligand. The invention further provides for a theranostic peptide agent and methods for use in the treatment of cancer and/or inflammation in a subject.

Peptide compositions for immuno-oncology molecular imaging and targeted drug delivery

Several embodiments disclosed herein relate to compositions and methods for treating or repairing damage to ocular tissue. In particular, several embodiments relate to patches that interact, e.g., by way of an adhesive, with damaged retinal tissue to repair or mend a hole, tear or detachment of the retina from underlying ocular tissue. Still additional embodiments relate to self-assembling patches.

Polymer substrate retinal patch coated with adhesives

The present disclosure describes, among other things, a thereto-responsive hydrogel comprising a PNIPAM copolymer having adhesive properties that are temperature dependent, as well as a device for administering the hydrogel, and methods for making and using the foregoing.

System for sutureless closure of scleral perforations and other ocular tissue discontinuities

The present disclosure describes, among other things, a thermo-responsive hydrogel comprising a PNIPAM copolymer having adhesive properties that are temperature dependent, as well as a device for administering the hydrogel, and methods for making and using the foregoing.

A method for growing a graphene layer on a metal foil includes placing a vessel into a chemical vapor deposition chamber, the vessel having a metal foil positioned therein. The method includes evacuating the chemical vapor deposition chamber, introducing hydrogen gas into the chamber to achieve a first pressure less than atmospheric pressure, heating the atmosphere in the chamber to anneal the metal foil, introducing methane and hydrogen into the chamber to achieve a second pressure less than atmospheric pressure.

Vapor-trapping growth of single-crystalline graphene flowers

Methods, materials and apparatus are described for synthesizing a monolayer or few-layers of graphene. Depositing the graphene can include, in some implementations, flowing hydrogen and carbon feedstock over a catalytic layer formed on a substrate.

Synthesis of graphene by chemical vapor deposition

A dental floss device comprises an elongated handle with a U-shaped flossing head projecting from one end of the handle. A strand of dental floss originated from a supply spool containing pre-wound fresh floss passes through the flossing head and emerges back to a take-up spool for containing spent floss. Dispensing floss and providing tension on the floss are controlled by the fingers of the holding hand on both supply spool and take-up spool which are rotatably mounted on the handle. The spools are also detachably mounted on the handle so that spent floss can be discarded and the take-up spool can be cleaned at will with ease and exhausted supply spools can easily be replaced with new, pre-wound spools like cartridges thus making the device reusable.

Growing community of inventors

Cypress, CA, United States of America

Yi Zhang