Novartis Ag

Alcon, Inc.

The Nippon Synthetic Chemical Industry Co., Ltd.

Shin-etsu Silicones of America, Inc.

Novartis Pharma Gmbh

Yasuo Matsuzawa

Lynn Cook Winterton

Yongxing Qiu

Frank Chang

Bernhard Seiferling

John Martin Lally

Xinming Qian

Harald Bothe

Venkat Shankar

John Dallas Pruitt

Rafael Victor Andino

Allen Douglas Gilliard

Michael Nelson Wilde

Daqing Wu

Angelika Maria Domschke

Mitsuo Shibutani

Newton T Samuel

Chandana Kolluru

Masahiro Saito

Uwe Haken

Katharina Schmid

Katharina Nikolaus

Ellen Marie Ajello

Celeste Aguado

Heike Arndt

Horngyih Huang

Maria A Dunkle

Hirohiko Miura

Nicolae Enciu

Jiro Tsuchiya

Chong Chai Ting

The invention is related to a medical device comprising a core material made of a crosslinked silicone material and a hydrogel coating which is thermodynamically stable. The invention is also related to a method for producing such a medical device, especially a soft contact lens.

Soft silicone medical devices with durable lubricious coatings thereon

The invention is related to a method for producing silicone hydrogel contact lenses with a stable lubricious hydrogel coating thereon. A method of the invention comprises forming a plasma-reactive hydrophilic polymer hybrid base coating having reactive functional groups on a silicone hydrogel contact lens and heating the silicone hydrogel contact lens with the hybrid base coating in an aqueous solution of a water-soluble and thermally crosslinkable hydrophilic polymeric material to form a stable lubricious hydrogel coating thereon.

Method for producing contact lenses with durable lubricious coatings thereon

The present invention provides a crosslinkable prepolymer which can be used to produce crosslinked polymeric materials (or contact lenses containing the same) having a high strength and excellent durability. The present invention relates to a polyvinyl alcohol-based prepolymer containing a unit having a pendant 1,2-diol containing group and a unit having a specific crosslinkable functional group, as well as a molding using the same.

Crosslinkable polymer

A method of treating of a lens forming surface () of at least one mold half () of a mold for molding an ophthalmic lens, in particular of the lens forming surface of a glass mold half for molding a contact lens, especially a soft contact lens, includes the steps of:

Method of treating a lens forming surface of at least one mold half of a mold for molding ophthalmic lenses

The invention provides a method of coating and thereby affecting the surface properties of a substrate such as a contact lens or other ophthalmic device. The method comprises the steps of generating an atmospheric plasma flow from a working gas and controlling the continuity of the atmospheric plasma flow with a power generator, and, introducing the atmospheric plasma flow to a substrate surface.

Atmospheric plasma coating for ophthalmic devices

The invention provides a method for washing, with a water-based system, reusable molds for making silicone hydrogel contact lenses. The water-based washing system comprises an ethoxylated silicone polyether surfactant. The water-based system of the invention can effectively wash away silicone-containing components and other components of a lens formulation left behind on the molding surfaces of a reusable mold, after removing a silicone hydrogel contact lens cast molded in the reusable mold.

Method for making silicone hydrogel contact lenses

A contact lens and a method for manufacturing thereof are provided. The contact lens has a silicone contact lens base material and an amorphous carbon film formed in the silicone contact lens base material. The amorphous carbon film of the contact lens is formed by subjecting the silicone contact lens base material to a plasma polymerization under an atmosphere of a mixed gas comprising a hydrocarbon gas and an oxygen-containing gas. The contact lens has excellent oxygen permeability and a high refractive index.

Silicone contact lens and method for manufacturing thereof

An embodiment of the invention is a basket for holding ophthalmic lenses. A basket of the present invention has a lattice structure having a lens contacting side and an opposite lens non-contacting side, wherein the lens-contacting side of the lattice has a very sharp edge structure and the lens non-contacting side can be a normal solid surface to maintain the mechanical strength of the basket. A tray that comprises a plurality of baskets is another embodiment of the invention. In addition, the invention provides a stack assembly that comprises a plurality of trays each of which comprises a plurality of baskets.

Basket for holding a medical device

The invention relates to a process for the manufacture of a hydrophilic coating on a biomedical article, which comprises treating the biomedical article for a time period of &#x2266;5 minutes with a solution of an organic solvent comprising a polyanionic compound with a number average molecular weight Mof &#x3e;5000, wherein the solution comprises less than 10% by weight of water, and wherein the solution is devoid of a cationic polymer. The coated biomedical articles obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus especially useful in the field of ophthalmic devices.

Process for the coating of biomedical articles

The invention provides a cost-effective method for making a silicone hydrogel contact lens having an LbL coating thereon that is not covalently attached to the lens and has good hydrophilicity, intactness and durability. The method comprises LbL coating at high temperature.

Method for applying a coating onto a silicone hydrogel lens

The present invention provides a method and a container for sterilizing a soft contact lens and for providing a sterilized storage package of the soft contact lens maintained in a packaging solution. By using the method and container of the invention, deformations of soft contact lenses during autoclave can be substantially reduced.

Method and kits for sterilizing and storing soft contact lenses

This invention provides a method for efficiently applying a coating to each of a plurality of objects selected from the group consisting of ophthalmic lenses, molds for making ophthalmic lenses, and other medical devices, the method comprising dipping the plurality of objects into a coating bath containing a coating solution having a coating material; and creating with a means a convective current flow and thereby forcing a coating solution flowing over and under each of the plurality of ophthalmic lenses. In a preferred embodiment, the plurality of objects are held in baskets which are pre-conditioned to have a first layer of polyelectrolytes and a second layer of aqueous solution or have a mixed layer of polyelectrolytes and aqueous solution on the surfaces of the baskets.

Method for applying a coating to a medical device

An apparatus and method for the production of ophthalmic lenses, and particularly contact lenses, which minimizes damage of the lens in removal from the mold. The ophthalmic lens is produced in a mold having a male part and a female part that are placed in proximate relation to each other to create a lens-forming cavity. At least the female surface of the female part mold is preferably coated with plasma and is irradiated for a predetermined time such that the female surface and/or surface coating is at least partially cured. Once the female surface, and alternately the male surface and other surfaces of the mold, is at least partially cured, a curable lens-forming material is placed into the lens-forming cavity and cured to form an ophthalmic lens.

Apparatus and method for the production of ophthalmic lenses

The invention provides a method for plasma coating of optical lenses, particularly lenses made of silicone-containing polymer. The method of the invention comprising selectively depressurizing and pressurizing an entry hold chamber and an exit hold chamber while constantly maintaining a plasma gas in a coating chamber at a process pressure without depressurizing and pressurizing repeatedly the coating chamber, wherein the coating chamber is located between the entry hold chamber and the exit hold chamber.

Growing community of inventors

Roswell, GA, United States of America

Yasuo Matsuzawa