University of Washington

University of Utah Research Foundation

Institute for Research in Biomedicine

Yang Hsia

David Baker

Neil P King

Marc J Lajoie

Jacob Bale

Wesley Sundquist

Elizabeth Gray

Daniel Stetson

Joerg Votteler

Gabriel Butterfield

Antonio Lanzavecchia

Lance Joseph Stewart

Jorge Fallas

Jessica Marcandalli

Brooke Fiala

Laurent Perez

Brooke Nickerson

Disclosed herein are nanostructures and their use, where the nanostructures include

Self-assembling protein nanostructures displaying paramyxovirus and/or pneumovirus F proteins and their use

The application discloses multimeric assemblies including multiple oligomeric substructures, where each oligomeric substructure includes multiple proteins that self-interact around at least one axis of rotational symmetry, where each protein includes one or more polypeptide-polypeptide interface ('O interface'); and one or more polypeptide domain that is capable of effecting membrane scission and release of an enveloped multimeric assembly from a cell by recruiting the ESCRT machinery to the site of budding by binding to one or more proteins in the eukaryotic ESCRT complex ('L domain'); and where the multimeric assembly includes one or more subunits comprising one or more polypeptide domain that is capable of interacting with a lipid bilayer (&#x201c;M domain&#x201d;), as well as membrane-enveloped versions of the multimeric assemblies.

Polypeptide assemblies and methods for the production thereof

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Seattle, WA, United States of America

Yang Hsia