Wyeth Holdings Corporation

Agenus Inc.

Xiaoyan Mo

Stephen Alexander Udem

Ramesh Kashi

Alemseged Truneh

Timothy Joseph Zamb

Gerald R Kovacs

Nikolaos Vasilakis

Daniel Lewis Levey

Kenneth P Leclair

Chuanliang Liu

Sangeeta Bhargava

The present invention relates to methods and compositions for the prevention and treatment of herpes virus infections. The invention provides antigenic peptides, and pharmaceutical compositions comprising complexes of antigenic peptides and adjuvants that can activate an immune response against herpes viruses. The invention also provides methods of making the antigenic peptides and complexes of antigenic peptides and adjuvants. Methods of use of the pharmaceutical compositions are also provided.

Vaccine for treatment and prevention of herpes simplex virus infection

Self-propagating, fusogenic blebs are produced from cells infected with a population of Venezuelan Equine Encephalitis virus replicon particles (VRP). The self-propagating, fusogenic nature of the blebs is derived from expression of heterologous genes encoding viral fusion proteins that are incorporated into the replication defective replicon particles. The resulting blebs can be harvested from supernatants of cells displaying severe cytopathic effects. The blebs are used to make immunogenic compositions and devise methods of immunizing mammals against paramyxoviruses such as parainfluenza virus type 3.

Fusogenic, self-propagating blebs as immunogenic compositions

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Boxborough, MA, United States of America

Xiaoyan Mo