Dow Agrosciences LLC

Lexington Pharmaceuticals Laboratories, LLC

William Randal Erickson

Stephen Craig Fields

Carla Nanette Yerkes

Yuanming Zhu

Christian Thomas Lowe

Terry William Balko

Brent Jeffrey Rieder

William Kirkland Brewster

Carla Jean Rasmussen Klittich

Gary D Crouse

Kevin Gerald Meyer

Noormohamed Mohamed Niyaz

David Anthony Demeter

Thomas L Siddall

Steven H Shaber

Gerald Bryan Watson

Michael Thomas Sullenberger

Zoltan Laszlo Benko

James Michael Gifford

James Edward Hunter

Gary David Gustafson

Nailah Orr

Nneka Tuere Breaux

Michael John Ricks

Jaime Susanne Nugent

Maurice Chee Hoong Yap

Frisby Davis Smith

Thomas Lyman Siddall

Jamie Susanne Nugent

Disclosed is a method of chlorinating a carbohydrate or derivative thereof, for example, a sucrose-6-ester at the 4,1', and 6&#x2032; positions, with irreversible removal of HCl formed during the reaction to form the chlorinated carbohydrate or derivative thereof, for example, a 4,1&#x2032;,6&#x2032;-trichloro-4,1&#x2032;,6&#x2032;-trideoxy-6-O-ester of galactosucrose (TGS-6E). The irreversible removal of HCl can be carried out by an irreversible physical process and/or an irreversible chemical process. Sucralose, an artificial sweetener, can be prepared by deesterification of the TGS-6E. The chlorination reaction takes place at low temperatures and the desired chlorinated product is obtained in high yields and in high purities.

Low temperature, vacuum assisted chlorination of sucrose-6-esters free of overchlorinated by-products as intermediates for the production of the artificial sweetener, sucralose

Disclosed is a method for chlorinating a carbohydrate or a derivative thereof to produce a polychlorinated carbohydrate or a derivative thereof, such as sucralose, the method involves (i) reacting the carbohydrate or derivative thereof with a chlorinating agent to obtain a reaction mixture comprising said polychlorinated carbohydrate or derivative thereof and at least one under-chlorinated carbohydrate or derivative thereof, (ii) returning the at least one under-chlorinated carbohydrate or derivative thereof to a chlorinating step and further chlorinating the at least one under-chlorinated carbohydrate or derivative thereof to obtain the desired polychlorinated carbohydrate or derivative thereof; and (iii) optionally repeating steps (i) and (ii) 'n' times where n&#x2267;1. The polychlorinated carbohydrate or a derivative thereof is obtained in high yields.

Chlorination of carbohydrates and carbohydrate derivatives

The invention disclosed in this document is related to field of pesticides and their use in controlling pests.

Pesticidal compositions

The present invention provides compounds of formula (I), thieno[2,3-d]pyrimidines, having fungicidal activity. 

Substituted thieno[2,3-D]pyrimidines as fungicides

The present invention relates to thieno[2,3-d]-pyrimidine compounds having fungicidal activity. Specifically, the present invention relates to compounds having the Formula (I): wherein each R1, R2 and R3 is independently selected from the group consisting of H, halogen, and alkyl; A is selected from the group consisting of H and alkyl; W is selected from the group consisting of NH and O; D is selected from O, NH and S; E is (&#x2014;C(O)&#x2014;)&#x2014;R', wherein p is 0 or 1 and R&#x2032; is selected from the group consisting of optionally substituted rings selected from phenyl. furanyl, pyridinyl, pyridinyl-N-oxide, pyrimidinyl, pyridazinyl, pyrazinyl, thiazolyl, triazinyl, thiadiazolyl, oxazolyl, isoxazolyl, thienopyrimidinyl, and pyrimidine fused with an aromatic or heteroaromatic ring selected from bejizene, oxazole, isoxazole, furan, thiazole, pyrimidine, pyridine, pyrrole, pyrazine, and thionhene; each ring being ontionally substituted with one or more substituents selected from the group consisting of alkyl, alkenyl, alkynyl, halogen, haloalkyl, alkoxy, haloalkoxy, nitro, cyano, alkylsulfonyl, alkylsulfoxide, alkylthio, alkoxyiminoalkyl, alkylcarbonyl, alkoxycarbonyl, aminocarbonyl, hydroxycarbonyl, phenyicarbonyl, forrnyl, hydrazidocarbonyl, amidoamino, pyrazolyl, triazolonyl, oxadiazolyl, phenyl, nyridinyl, and phenoxyalkyl; B is selected from the group consisting of halogen, alkyl, haloalkyl, and haloalkoxy; n is an integer from 0 to 3; and m is an integer from 0 to 4 with the proviso that when D is O or S and E is phenyl, then E is not further substituted with halogen.

Thieno-pyrimidine compounds having fungicidal activity

This invention relates to substituted dihydrotriazinones, triazinones and related compounds, compositions comprising such compounds and an agronomically acceptable carrier, and the use thereof as broad spectrum fungicides. This invention also teaches methods of preparing these compounds as well as methods of using the compounds as fungicides.

Substituted 4,5-dihydro-1,2,4-triazin-6-ones, 1,2,4-triazin-6-ones, and their use as fungicides

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Carmel, IN, United States of America

William Randal Erickson