Baxter International Inc.

William R Thomas

Melaine Alpern

Stanley T Enomoto

Samia S Mankarious

Daphne C Tse

Shu Len Liu

Cataline M Garanchon

A method for preparing a fibrinogen-containing composition derived from human plasma by separating a cryoprecipitate from the plasma, suspending the cryoprecipitate in a salt-containing buffer, treating the supernatant by affinity-chromatography on a lysine-bound solid matrix to allow plasminogen to adsorb thereon, collecting a fraction containing less than 10 .mu.g/ml plasminogen, and treating the fraction to reduce viral activity. The fibrinogen-containing composition recovered from this fraction is advantageous because it contains such a low amount of plasminogen that no addition of fibrinolysis inhibitor is needed.

Method of preparing a topical fibrinogen complex

A composition which, upon reacting with thrombin, functions as a fibrin sealant and is characterized as being free of detectable levels of lipid enveloped virus activity, free of prothrombin complex and active thrombin, and contains no protease inhibitors or other non-human proteins. Also, described is a method for producing the composition.

Topical fibrinogen complex

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Laguna Niguel, CA, United States of America

William R Thomas