Research Development Foundation

The University of Texas System

William Kelton

George Georgiou

Sang Taek Jung

Tae Hyun Kang

Nishant Mehta

Antibody Fc polypeptides are provided that efficiently bind to both Fc&#x3b3; and Fc&#x3b1; receptors. In certain aspects, a Fc polypeptide comprises a chimeric IgG CH2 domain having a &#x3b1;1 loop from IgA and an IgA CH3 domain. Recombinant antibodies comprising Fc polypeptides of the embodiments and methods for making and using such antibodies are likewise provided.

Antibodies with engineered IgG Fc domains

Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain. In certain embodiments, polypeptides have an aglycosylated Fc domain that contains one or more substitutions compared to a native Fc domain. Additionally, some embodiments involve an Fc domain that is binds some Fc receptors but not others. For example, polypeptides are provided with an aglycosylated Fc domain that selectively binds Fc&#x3b3;RIIa, but that is significantly reduced for binding to the highly homologous Fc&#x3b3;RIIb receptors. Furthermore, methods and compositions are provided for promoting antibody-dependent cell-mediated toxicity (ADCC) using a polypeptide having a modified aglycosylated Fc domain and a second non-Fc binding domain, which can be an antigen binding region of an antibody or a non-antigen binding region. Some embodiments concern antibodies with such polypeptides, which may have the same or different non-Fc binding domain.

Growing community of inventors

Austin, TX, United States of America

William Kelton