Njoy, Inc.

Covalent Research Technologies, LLC

Milliken & Company

Wesley Freund

Douglas Sawyer

Bert Willis

Mohammed Moinuddin Ahmed

Jared K Nelson

Peter W Newsome

Robert Blalock Calmes, Jr

Rudolph C Schmidt, Jr

Lisa Yvonne Blue

Nicholas L'AMOREAUX

The present disclosure generally relates to methods of preparing nicotine and resolving R,S nicotine to enrich the (S)(&#x2212;) enantiomer. The method may comprise combining N-methyl-2-pyrrolidone or a salt thereof with a nicotinate compound in the presence of a solvent and a strong base to form 1-methyl-3-nicotinoyl-2-pyrrolidone or a salt thereof; and reducing the 1-methyl-3-nicotinoyl-2-pyrrolidone or salt thereof in solution with NaSOto produce racemic nicotine or salt thereof. Resolving the racemic nicotine (or other enantiomeric mixture) may comprise combining the nicotine with (&#x2212;)-O,O'-di-p-toluoyl-L-tartaric acid (L-PTTA).

Synthesis and resolution of nicotine

Solid-supported trithiol compounds are prepared. The solid-supported trithiol compounds have formula (I): in which R is a linker moiety, X is a solid support, and n&#x2267;1. The compounds of formula (I) may be incorporated into methods for removing heavy metals from solutions and into batch systems or filtration apparatus that remove heavy metals from solutions.

Solid supported trithiol compounds for removing heavy metals from solution, and filtration systems utilizing the compounds

Growing community of inventors

Arden, NC, United States of America

Wesley Freund