Glycofi, Incorporated

Glycan Biosciences LLC

Merck Sharp + Dohme Corp.

Glycan Bioscience LLC

Avitide LLC

Paradigm Biopharmaceuticals Ltd

Warren Charles Kett

Piotr Bobrowicz

W James Cook

Yugang Chen

Deirdre Roma Coombe

Sarah Valentini

Thomas Scanlon

Brandon Coyle

William Scott Dodson

Brandon Kier

James W Cook

Provided herein are affinity agents comprising ligands that specifically bind adeno-associated virus. The affinity agents are useful for binding, isolation, and/or purification of adeno-associated virus. Further disclosed are amino acid sequences of binding motifs or polypeptides comprised by the ligands, and associated modifications of the binding motifs and/or polypeptides, as well as a method of making the affinity agents.

AAV9 affinity agents

The invention relates to anionic conjugates of glycosylated bacterial metabolites that may be used to mimic the structure and/or activity of the anionic bioactive molecules known as glycosaminoglycans (GAGs). The invention also relates to processes for the preparation of the conjugates. Such conjugates are useful in the prophylaxis and/or treatment of disease conditions and in particular chronic disease conditions such as inflammatory (including allergic) diseases, metastatic cancers and infection by pathogenic agents including bacteria, viruses or parasites.

Anionic conjugates of glycosylated bacterial metabolite

A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of an inhibitor of Pmt-mediated O-linked glycosylation and/or in the presence of one or more &#x3b1;-1,2-mannosidases.

Production of glycoproteins with reduced O-glycosylation

The invention relates to anionic oligosaccharide conjugates that may be used to mimic the structure and/or activity of the anionic bioactive molecules known as glycosaminoglycans (GAGs).

Anionic oligosaccharide conjugates

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West Lebanon, NH, United States of America

Warren Charles Kett