Merck + Co., Inc.

Walter E Manger

Robert D Sitrin

Mark S Rienstra

Ann L Lee

Qinjian Zhao

Shishir Gadam

Shilu Wu

Human papillomavirus virus-like particles (VLPs) are subjected to various maturation conditions, including incubation at higher temperatures, exposure to soluble metals or thios-oxidation. The resultant matured VLPs are more stable, and can be used to make a vaccine formulation with increased shelf life and higher potency.

Process for making human papillomavirus virus-like particles with improved properties

A process for converting lipid-containing bacterial capsular polysaccharide, such as lipo-polyribosyl ribitol phosphate, lipo-PRP, into lipid-free, endotoxin-free polysaccharide, such as polyribosyl ribitol phosphate, PRP, by solubilizing polysaccharide-containing powder derived from culture media of bacteria, such as Haemophilus influenzae type b, cleaving covalently bound fatty acids from the polysaccharide, and removing the lipids, and endotoxin.

Process for converting lipid-containing bacterial capsular

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Harleysville, PA, United States of America

Walter E Manger