Wayne State University

Unversität Zürich

Vikram Sarpe

Andrea Vasella

Sven N Hobbie

David Crich

Erik C Bottger

Takayuki Kato

Amr Sonousi

Guanyu Yang

Jonathan Quirke

Appi Reddy Mandhapati

Parasuraman Rajasekaran

Girish Sati

Michael G Pirrone

The invention relates to derivatives of apramycin-based aminoglycoside antibacterial drugs modified in positions C5 and/or C6 and O5 and/or O6. The modifications impart favourable properties regarding increased selectivity and retention of activity in the presence of resistance determinants of the AAC(3) class. The invention further relates to said compounds for use in the therapy of bacterial infection by systemic administration, especially in instances where the infection is caused by a pathogen comprising a resistance determinant of the AAC(3) class, in particular AAC(3)-IV.

Apramycin derivatives

The present disclosure relates to derivatives of neamine-based aminoglycoside antibacterial drugs modified in position C6', C2&#x2032; and/or C5&#x2033;. The modifications impart favorable properties regarding activity against ESKAPE pathogens, evasion of resistance traits and increased selectivity, enabling systemic use of the compounds.

Neomycin and paromomycin derivatives

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Detroit, MI, United States of America

Vikram Sarpe