Codexis, Inc.

Syntis Bio, Inc.

Vesna Mitchell

Xiyun Zhang

Jeffrey C Moore

Nikki Dellas

Oscar Alvizo

Jovana Nazor

Gjalt W Huisman

Robert Osborne

Da Duan

Erika M Milczek

Khin Yu Naing Htwe

David Elgart

Christopher K Savile

Agustina Rodriguez-Granillo

Nicholas M Marshall

Xiang Yi

Robert Kevin Orr

Courtney Dianne Moffett

Katrina W Lexa

Scott J Novick

Grant S Murphy

Jonathan Vroom

Jack S Liang

Keith Allen Canada

Mark A Huffman

Deeptak Verma

Jay Russell

Steven James Collier

Yong Koy Bong

James Nicholas Riggins

Ravi David Garcia

Anna Fryszkowska

Jagadeesh Mavinahalli

Michael Vogel

Ericka Bermudez

David Entwistle

Mathew G Miller

Iman Farasat

Nandhitha Subramanian

Jonathan S Penfield

Judy Victoria Antonio Viduya

Santhosh Sivaramakrishnan

Emily Mundorff

Rama Voladri

Richard John Fox

Birthe Borup

Auric Anthony Sowell-Kantz

Christopher Michael Micklitsch

Donald Scott Baskerville

Antoinette Sero

Nikki D Kruse

Sandy M Gomes

Grzegorz Wojciechowski

Douglas E Fuerst

Brent Dorr

Derek J Smith

Wei Zhang

Lorraine Joan Giver

Benjamin Mijts

Lisa Marie Newman

Charlene Ching

S Christopher Davis

James Joseph LaLonde

Ellen D Eberhard

Ee Lui Ang

Lynne Gilson

Stephanie Sue Galanie

Kristen Jean Vallieu

Kerryn McCluskie

James LaLonde

Jeffrey Colbeck

Jing Tian

Leann Quertinmont Teadt

Bumshik Robert Pak

Kierra Aleece Franklin

Khin Yu Htwe

The present invention provides engineered phosphopentomutase (PPM) enzymes, polypeptides having PPM activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PPM enzymes are also provided. The present invention further provides compositions comprising the PPM enzymes and methods of using the engineered PPM enzymes. The present invention finds particular use in the production of pharmaceutical compounds.

Engineered phosphopentomutase variant enzymes

The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related vectors, host cells, and methods for making the engineered enone reductase polypeptides. The disclosure also provides methods of using the engineered enone reductase polypeptides for chemical transformations.

Enone reductases

The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.

P450-BM3 variants with improved activity

The present invention provides engineered carboxyesterase enzymes having improved properties as compared to a naturally occurring wild-type carboxyesterase enzymes, as well as polynucleotides encoding the engineered carboxyesterase enzymes, host cells capable of expressing the engineered carboxyesterase enzymes, and methods of using the engineered carboxyesterase enzymes in amidation reactions.

Carboxyesterase polypeptides for amide coupling

The present invention provides engineered ketoreductase and phosphite dehydrogenase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase and phosphite dehydrogenase enzymes, as well as polynucleotides encoding the engineered ketoreductase and phosphite dehydrogenase enzymes, host cells capable of expressing the engineered ketoreductase and phosphite dehydrogenase enzymes, and methods of using the engineered ketoreductase and phosphite dehydrogenase enzymes to synthesize a chiral catalyst used in the synthesis of antiviral compounds, such as nucleoside inhibitors. The present invention further provides methods of using the engineered enzymes to deracemize a chiral alcohol in a one-pot, multi-enzyme system.

Ketoreductase polypeptides and polynucleotides

The present disclosure relates to engineered DNA polymerase polypeptides and compositions thereof, as well as polynucleotides encoding the engineered DNA polymerase polypeptides. The present disclosure also provides methods of using the engineered DNA polymerase polypeptides or compositions thereof for diagnostic and other purposes.

Engineered DNA polymerase variants

The present invention provides engineered methionine gamma lyase polypeptides and compositions thereof. The engineered methionine gamma lyase polypeptides have been optimized to provide improved thermostability, protease stability, and stability under a range of pH conditions, including acidic (pH<7) conditions. The present invention also relates to the use of the compositions comprising the engineered methionine gamma lyase polypeptides for therapeutic purposes.

Engineered methionine gamma lyase variants

The present invention provides engineered purine nucleoside phosphorylase (PNP) enzymes, polypeptides having PNP activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PNP enzymes are also provided. The present invention further provides compositions comprising the PNP enzymes and methods of using the engineered PNP enzymes. The present invention finds particular use in the production of pharmaceutical compounds.

Engineered purine nucleoside phosphorylase variant enzymes

The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.

Penicillin-G acylases

The present invention provides engineered DNA polymerase polypeptides and compositions thereof, as well as polynucleotides encoding the engineered DNA polymerase polypeptides. The invention also provides methods for use of the compositions comprising the engineered DNA polymerase polypeptides for diagnostic and other purposes.

The present invention provides engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.

Growing community of inventors

Santa Clara, CA, United States of America

Vesna Mitchell