E. R. Squibb Sons, Inc.

Venkatachala L Narayanan

Rudiger D Haugwitz

Frederic P Hauck

Christopher M Cimarusti

Joseph E Sundeen

Joyce Reid

Glenn A Jacobs

Hans H Gadebusch

Raymond R Pilote

Jeremiah J O'Connor

Linda Louise Setescak

George C Rovnyak

Frank L Weisenborn

Richard G Angel

The rate of growth and feed efficiency of ruminants is increased by adding to the feed of ruminants an effective amount of the trichloroethyl ester of an essential amino acid.

Ruminant feeds containing trichloroethyl esters of essential amino acids

5,6,7,8-Tetrahydro-1,6,7-naphthalenetriols having the formula ##STR1## wherein R.sup.8, R.sup.9 and R.sup.10 are the same or different and are hydrogen, lower alkyl, monocyclic aryl-lower alkyl, lower alkoxy, carboxy, or monocyclic cycloalkyl, are intermediates useful in the preparation of compounds used to treat coronary diseases.

5,6,7,8-Tetrahydro-1,6,7-naphthalenetriols

Diene intermediates for indantetrols are provided having the structure ##STR1## wherein X is a single bond or a straight or branched chain alkylene group containing from 1 to 10 carbons, Y is ##STR2## wherein R.sub.7 is hydrogen, lower alkyl, arylalkyl or lower alkoxy and ##STR3## is taken together to form a piperidyl or pyrrolidyl radical, R.sub.8 and R'.sub.8 are lower alkyl or monocyclic cycloalkyl, n is 1 to 3, m and m' are 0, 1 or 2.

Diene intermediates for indantetrols

Compounds are provided having the structure ##STR1## WHEREIN N IS 1, 2 OR 3, M AND M' ARE 0, 1 OR 2, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be the same or different and can be hydrogen, lower alkyl, halolower alkyl, acyl, lower alkoxy-carbonyl ##STR2## or lower alkoxyalkylene, X is a straight or branched bivalent aliphatic radical and Y is ##STR3## These compounds are useful in the treatment of hypertension.

Indantetrol derivatives

Compounds are provided having the formula ##STR1## which compounds are useful as anthelmintics, and anti-fungal and anti-bacterial agents. In addition, methods for preparing such compounds, intermediates prepared in such methods, useful compositions containing such compounds and methods for employing such compounds and compositions containing the same are also provided.

3-Hetero-5-isothiocyanophenyl oxadiazoles as antifungal and

Indolinone compounds which exhibit anti-inflammatory activity have the following formula ##STR1## wherein R.sup.1, R.sup.3, R.sup.4, R.sup.5, and n are as defined herein.

1,3,Thiazolinyl and 1,3 thiazinyl substituted indolinones

Compounds are provided having the structure ##STR1## wherein n is 1, 2 or 3, m is 0, 1 or 2, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 may be the same or different and can be hydrogen, lower alkyl, halo-lower alkyl, acyl, lower alkoxy-carbonyl ##STR2## amido ##STR3## or lower alkoxyalkylene, X is a straight or branched bivalent aliphatic radical and Y is ##STR4## These compounds are useful in the treatment of hypertension.

Indanpentol derivatives

Compounds are provided having the structure ##STR1## WHEREIN N IS 1, 2 OR 3, M AND M' ARE 0, 1, OR 2, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be the same or different and can be hydrogen, lower alkyl, halolower alkyl, acyl, lower alkoxy-carbonyl ##STR2## or lower alkoxyalkylene, X is a straight or branched bivalent aliphatic radical and Y is ##STR3## These compounds are useful in the treatment of hypertension.

4,7-Dihydroindanyl alkanols, analogues thereof and their corresponding

Compounds having the formula ##STR1## wherein R.sup.1 is lower alkyl; R.sup.3, R.sup.4, R.sup.5, R.sup.6, and R.sup.7 are the same or different and are hydrogen or lower alkyl; R.sup.8, R.sup.9, and R.sup.10 are the same or different and are hydrogen, lower alkyl, lower alkoxy or cycloalkyl; and R.sup.11 is acyl; are useful in the treatment of coronary diseases.

Esters of tetrahydronaphthyloxy-aminopropanols

3-Pyridinyl-5-isothiocyanophenyl oxadiazoles

Isothiocyanobenzoxazoles having the structure ##STR1## wherein R.sub.1 is hydrogen, alkyl, alkoxy, or halogen; X is O or S; R.sub.2 is 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, 4-thiamorpholinyl, 4-alkyl-1-piperazinyl, 4-alkyl-1-piperidinyl or 3-alkyl-1-pyrrolidinyl, are useful anthelmintic agents.

Isothiocyanobenzoxazoles

Compounds of the formula ##STR1## and their acid-addition salts wherein X is O or S; R is hydrogen, lower alkyl, phenyl, chloro, bromo, trifluoromethyl, lower alkoxy, phenoxy, or di(lower alkyl)amino; R.sup.1 is hydrogen, lower alkyl, phenyl, substituted-phenyl, cycloalkyl, or heterocyclic; and R.sup.3 is lower alkyl, substituted-lower alkyl, cycloalkyl, lower alkenyl, lower alkynyl, phenyl, or substituted phenyl; are disclosed. These compounds exhibit anthelmintic and antibacterial and antifungal activity.

[(1,2,4-Oxadiazol-3-yl)phenyl]carbamic or thiocarbamic acid esters

Isothiocyanobenzothiazoles are provided having the structure ##SPC1## Wherein R and R.sup.1 are as indicated below, and which are useful as anthelmintic agents.

Isothiocyanobenzothiazoles

Isothiocyanobenzoxazoles are provided having the structure ##SPC1## Wherein R.sup.1 is pyridyl or pyridyl substituted with alkyl, halogen, acetoxyalkyl or dialkylaminoalkyl and R.sup.2 is hydrogen, alkyl, halogen or alkoxy are useful anthelmintic agents and disinfectants.

Growing community of inventors

Hightstown, NJ, United States of America

Venkatachala L Narayanan