Advanced Bionutrition Corporation

Trisha Rice

Moti Harel

Brian Carpenter

Roger Drewes

January Scarbrough

Qiong Tang

Kimberly Jennings

Elizabeth Raditsis

Mordechai Harel

Majid Keshtmand

A dry stable probiotic composition is provided. The composition comprises one or more viable probiotic microorganisms, one or more hydrolyzed proteins, one or more disaccharides, one or more oligosaccharides, and one or more polysaccharides, but not trehalose. The composition has viability of at least 1&#xd7;10CFU/g, and a viability loss of less than 1 log unit/g after 3 months at a temperature of 40&#xb0; C. and a relative humidity of 33%. Also provided are methods for preparing the dry stable probiotic composition.

Stable dry probiotic compositions for special dietary uses

A dry stable composition is provided. The composition comprises one or more viable microorganisms, at least 50% by weight of one or more hydrolyzed proteins and less than 10% by weight of one or more sugars selected from the group consisting of monosaccharides, disaccharides and combinations thereof, each weight percentage based on the total weight of the dry composition. Preferably, the composition comprises no monosaccharide or disaccharide. The composition may further comprise one or more oligosaccharides, one or more polysaccharides, one or more carboxylic acid salts, or a combination thereof. The composition may have viability of at least 1&#xd7;10CFU/g, and a viability loss of less than 1 log unit/g after 84 days at a temperature of 40&#xb0; C. and a relative humidity of 33%. Also provided are methods for preparing the dry stable composition.

Stable dry compositions having no or little sugars

Dry stabilizing compositions for bioactive materials include sugars and hydrolyzed proteins, and may be formed into tablets or other forms providing enhanced stability for the bioactive material. Compositions containing the bioactive materials may be produced by a method that includes (a) combining the bioactive material with other ingredients in an aqueous solvent to form a viscous slurry; (b) snap-freezing the slurry in liquid nitrogen to form solid frozen particles, beads, droplets or strings; (c) primary drying by water removal under vacuum of the product of step (b) while maintaining it at a temperature above its freezing temperature; and (d) secondary drying of the product of step (c) at maximum vacuum and a temperature of 20&#xb0; C. or higher for a time sufficient to reduce the water activity to below 0.3 Aw.

Stabilizing composition for biological materials

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Columbia, MD, United States of America

Trisha Rice