Givaudan S.a.

Thomas Scott McCluskey

Jay Patrick Slack

Stefan Michael Furrer

Karen Ann Bell

David Max Dastrup

G-chimeric G-proteins that functionally couple to G-protein coupled receptors. The chimeras can be expressed in heterologous cell systems and can be used as the basis of assays for identifying modulators of taste response, in particular bitter, sweet or umami taste responses.

G-proteins

Compounds of formula (I) wherein R-R5, n and m have the same meaning as given in the description, having cooling properties are disclosed. Furthermore a process of their production and consumer products comprising them are disclosed.

Carboxamide derivatives having cooling properties

Cooling compounds of formula (I) wherein Ris selected from the group consisting of hydrogen, methyl, C-Calkoxy, phenyl, C-Calkylphenyl, C-Calkoxyphenyl, thienyl, pyridyl, furyl, and indoyl;Ris selected from the group consisting of hydrogen and hydroxyl, orRforms together with the carbon atom to which it is attached a carbonyl group; andRis selected from the group consisting of 2,4-dimethylpent-3-yl, 2,3,4-trimethylpent-3-yl, adamantyl and 2-isopropyl-5-methyl-cyclohexyl-1-yl; and, product compositions comprising them.

Butone derivatives useful as cooling agents

Gchimeric G-proteins that functionally couple to G-protein coupled receptors. The chimeras can be expressed in heterologous cell systems and can be used as the basis of assays for identifying modulators of taste response, in particular bitter, sweet or umami taste responses.

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Amelia, OH, United States of America

Thomas Scott McCluskey