Immulogic Pharmaceutical Corporation

Merck Patent Gmbh

Immulogic, Inc.

Thomas J Briner

Malcolm L Gefter

Julia L Greenstein

Mei-chang Kuo

Barbara S Fox

Mark A Exley

Richard D Garman

Stephen P Powers

Victoria C Schad

Malcolm Morville

Philip A Swain

Jay Paul Morgenstern

Bruce L Rogers

Ze'ev Shaked

Julian F Bond

Andrew W Brauer

Irwin J Griffith

A substantially pure, covalently linked human T cell reactive feline protein (TRFP) has been isolated from vacuum bag extract obtained by affinity purification of house dust collected from several homes with cats; DNA encoding all or a portion of the TRFP or peptide; compositions containing such a protein or peptide or portions thereof; and antibodies reactive with the TRFP or peptide are disclosed. Also disclosed are recombinant TRFP or peptide; modified or mutated TRFP peptides; their use for diagnostic or therapeutic purposes.

Human T cell reactive feline protein (TRFP) isolated from house dust and uses therefor

Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo are disclosed. Methods of preparing the hapten-carrier conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs.

Hapten-carrier conjugates for use in drug-abuse therapy and methods for

Peptides of human T cell reactive feline protein (TRFP)

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Arlington, MA, United States of America

Thomas J Briner