Uti Limited Partnership

University Technologies International, Inc.

Agritope, Inc.

Exelixis Plant Sciences, Inc.

Thomas G Back

Richard Persons Pharis

Suanne K Nakajima

Noah Berkowitz

Dawei Jiang

S R Wayne Chen

Kannan Vembaiyan

Dusan Kuzma

Denise L Andersen

Gabriel Sung

The present invention provides novel ryanodine receptor type 2 (RyR2) inhibitors and methods of their use in the treatment of cardiac conditions. In general, the RyR2 inhibitors of the present invention assist in the normalization of intracellular calcium homeostasis. In certain embodiments, the RyR2 inhibitors are store-overload-induced Carelease (SOICR) inhibitors that minimally inhibit or do not inhibit Ca-induced Carelease (CICR), thereby providing beneficial effects in cardiac therapy.

Ryanodine receptor inhibitors and methods relating thereto

This invention relates to novel organoselenium and tellurium compounds, processes of producing the same and methods of use thereof. The compounds function as mimetics for the catalyst selenoenzyme glutathione peroxidase, which protects cells from oxidative stress.

Glutathione peroxidase mimetics and uses thereof

Non steroidal mimetics or analogues of brassinosteroids such as brassinolide include two bicyclic subunits each having a vicinal diol group and a polar unit and linked by a linking moiety such that the vicinal diol groups and polar unit are closely superimposable on corresponding functional groups in the brassinosteroid.

Non-steroidal mimetics of brassinolide

Disclosed are compositions and methods for promoting plant growth. The compounds are cyclopropyl-, cyclobutyl-, and cyclopentyl-substituted brassinosteroids having high growth promoting ability. They may be used alone or in combination with other plant growth regulating agents.

Brassinosteroid analogs useful as plant growth regulators

Disclosed are compositions and methods for promoting plant growth. The compounds are cyclopropyl- and cyclobutyl-substituted brassinosteroids having high growth promoting ability. They may be used alone or in combination with other plant growth regulating agents.

Growing community of inventors

Calgary, Canada

Thomas G Back