Medical Research Council

Cambridge Antibody Technology Limited

Terence Derek Prospero

James David Marks

Gregory Paul Winter

Andrew David Griffiths

Brian Timothy McGuinness

Magnus Malmqvist

Anthony Richard Pope

Kaspar-Philipp Holliger

Hendricus Renerus Jacobus Matheus Hoogenboom

Hendricus Renerus Hoogenboom

Kaspar-Philip Holliger

Polypeptides comprising a first domain, which comprises a binding region of an immunoglobulin heavy chain variable region, and a second domain, which comprises a binding region of an immunoglobulin light chain variable region, the domains being linked but incapable of associating with each other to form an antigen binding site, associate to form antigen binding multimers, such as dimers, which may be multivalent or have multispecificity. The domains may be linked by a short peptide linker or may be joined directly together. Bispecific dimers may have longer linkers. Methods of preparation of the polypeptides and multimers and diverse repertoires thereof, and their display on the surface of bacteriophage for easy selection of binders of interest, are disclosed, along with many utilities.

Multivalent and multispecific binding proteins, their manufacture and use

Multivalent and multispecific binding proteins and their use

Growing community of inventors

Cambridge, United Kingdom

Terence Derek Prospero