Otsuka Pharmaceutical Company, Limited

Otsuka Chemical Co., Ltd.

Cosmed Pharmaceutical Co., Ltd.

Takao Taki

Michiaki Tominaga

Toshiaki Matsumoto

Kentaro Tadano

Takuma Imada

Takuya Kishimoto

Izumi Hanya

Machiko Tsuji

Kunihiko Matsuoka

Yuko Uchiyama

Hiromasa Tsuneishi

Kyoko Kameda

Tania Valdes-Gonzalez

Koichi Ogino

Dai Ishikawa

Yusuke Kato

Takashi Hayashi

Fumio Kamiyama

Ying-shu Quan

Satoshi Shimizu

Michinori Tanaka

Takahiro Tomoyasu

Kazuaki Kakehi

Yasuo Koga

Hiroaki Asai

Fumitaka Goto

Kazuhide Ohta

Yoko Sakamoto

Minoru Kashimoto

Kazuyoshi Kawai

Junji Takaba

Naohiro Hayashi

Wakako Hirano

Atsushi Azuma

Naoto Oku

Tadayoshi Takemoto

Takuya Hamabuchi

Satoru Nakazato

Masaru Nishida

Kazunari Izumi

Ying-Shu Quan

The present invention relates to an extract obtained by extracting useful components containing equal from an equol-containing fermented soybean hypocotyl, and to a method for producing the same. The present invention makes it possible to efficiently obtain useful components containing equol from the fermented soybean hypocotyl by subjecting an equol-containing fermented soybean hypocotyl to extraction using an ethanol aqueous solution as an extractant. The present invention reduces the content of saponin, which causes an unpleasant taste, by sequentially subjecting the equal-containing fermented soybean hypocotyl to extraction using an ethanol aqueous solution and ethanol, while efficiently extracting equol and glycitein.

Equol-containing extract, method for production thereof, method for extraction of equol, and equol-containing food

A microneedle array is provided which has (1) the strength to withstand insertion into the skin surface layer and/or stratum corneum, (2) the fineness and flexibility to cause no pain or bleeding in the skin surface layer and/or stratum corneum at the insertion site of the microneedles, and (3) solubility or biodegradability of the microneedle portions under the skin. The microneedle array is produced by forming microneedles using proteoglycan as a base material.

Proteoglycan-containing microneedle array

The present invention relates to an extract obtained by extracting useful components containing equol from an equol-containing fermented soybean hypocotyl, and to a method for producing the same. The present invention makes it possible to efficiently obtain useful components containing equol from the fermented soybean hypocotyl by subjecting an equol-containing fermented soybean hypocotyl to extraction using an ethanol aqueous solution as an extractant. The present invention reduces the content of saponin, which causes an unpleasant taste, by sequentially subjecting the equol-containing fermented soybean hypocotyl to extraction using an ethanol aqueous solution and ethanol, while efficiently extracting equol and glycitein.

A low-molecular-weight polysulfated hyaluronic acid derivative useful for treatment of an allergic disease. An agent for treatment of an allergic disease selected from pollinosis, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, and asthma, represented by the following general formula (IA) or (IB); wherein n represents a number of 0 to 15; R's each independently represent a hydrogen atom or an SOH group etc.

Low-molecular polysulfated hyaluronic acid derivative and medicine containing same

GD3-Mimetic peptides which contain an amino acid sequence represented by any of SEQ ID NOS: 1 to 4 or an amino acid sequence derived therefrom by substitution, deletion, addition, or insertion of one or more amino acid residues and attaining specific binding to an anti-GD3 antibody; and medicinal compositions containing the same.

GD3-mimetic peptides

Angiogenesis-specific peptides which home selectively to neovascular tissues and comprise one of the peptides having the amino acid sequences shown in SEQ ID NOS: 1 to 17 and dendrimers thereof. These peptides are applicable to DDS preparations whereby drugs can be transported selectively to target cancer tissues and are useful as diagnostics for cancer, remedies for cancer, etc. which contribute to the improvement in the therapeutic effects on cancer.

Neovascular-specific peptides

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Osaka, Japan

Takao Taki