Yamasa Corporation

Eisai Company, Limited

Hokkaido University

Takao Koike

Eiji Matsuura

Yoshiko Igarashi

Hisato Nagae

Hiroshi Nishihara

Tomoyoshi Katahira

Mitsufumi Nishio

Tatsuya Atsumi

Makoto Igarashi

[Problems] To provide a marker which is useful in diagnosing leukemia and a method of using the same. [Means for Solving Problems] A method of detecting a leukemia cell which comprises detecting a CD34-positive cell being negative in DOCK180 expression from a blood specimen. According to this method, a DOCK180 expression pattern specific to a tumor cell in leukemia, in particular, acute leukemia is confirmed so that information which is useful in diagnosing leukemia and monitoring and determining the severity and degree of recovery of the same by a doctor can be obtained by a convenient procedure using blood specimens and thus provided.

Method of detecting leukemic cell

A monoclonal antibody having inhibitory activity on blood coagulation reactions, which reacts with prothrombin forming a complex with phosphatidylserine but does not react with prothrombin not forming a complex with phosphatidylserine; and a method for measuring inhibitory activity of test plasma on blood coagulation reactions, which comprises the steps of (1) measuring inhibitory activity of the test plasma on the blood coagulation reactions and inhibitory activity of this on the blood coagulation reactions, and (2) comparing the inhibitory activity of the test plasma with the inhibitory activity of this antibody.

Method of assaying lupus anticoagulant and assay reagent

Method of assaying autoimmune anticardiolipin antibody and kit therefor

Method for determination of oxidized lipoproteins and use thereof

Growing community of inventors

Sapporo, Japan

Takao Koike