Georgia Tech Research Corporation

Clark Atlanta University, Inc.

Subhasish Tapadar

Adegboyega K Oyelere

Verjine Khodaverdian

Silvia Caggia

Shafiq A Khan

Compositions and methods for inhibiting histone lysine demethylases are provided. Several new DFP-based KDM inhibitors which alter the velocity of HP1-mediated heterochromatin gene repression are provided.

3-(hydroxy)-pyridin-4(1H)-one compounds and methods of making and using the same

The disclosure relates to novel compounds and methods of use of the compounds to maintain the Gα2 protein in its inactive GDP-bound state. The disclosure describes the knockdown or inhibition of Gα2 negatively regulated migration of breast and ovarian cancer cell lines. The novel compounds inhibit the migratory behavior of PC3, DU145 and E006AA prostate cancer cell lines. Specifically, the novel compounds block the activation of Gα2 in oxytocin-stimulated prostate cancer PC3 cells and inhibits the migratory capability of DU145 cells overexpressing constitutively active form of Gα2, under basal and EGF-stimulated conditions.

Small molecule inhibitors of G(alpha)i2 protein and uses thereof

Compounds of Formula I or II, and methods of making and using thereof, are described herein. 

Growing community of inventors

Atlanta, GA, United States of America

Subhasish Tapadar