Baylor College of Medicine

Other

Johns Hopkins University

Genetronics, Inc.

Sophia Yang Tsai

Ming-Jer Tsai

Bert W O'Malley

Venkatesh Krishnan

Philip Arden Beachy

Chien-Huan Chen

Jason Fewell

Ronald V Abruzzese

Sergio Onate

Vidya Mehta

Phillip A Beachy

Chen-Huan Chen

Jeffrey L Nordstrom

Lee-Ho Wang

George Francis Allan

The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provided as well as methods for identifying compounds that are phosphatase inhibitors. Methods of treating tumors in a subject by modulating the phosphorylation of the transcription factor are also included.

Modulation of hedgehog-mediated signaling pathway

Disclosed is a novel inducible expression system characterized by undetectable biological effect in the absence of an inducer, but which exhibits efficient inducibility in the presence of an inducer.

Gene switch systems employing regulators with decreased dimerization

Method for identifying an agent that affects a hedgehog signaling pathway

The present invention relates to SRC-1 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for enhancing and inhibiting transcription by providing SRC-1 polypeptides or fragments thereof to a cell.

Steroid receptor coactivator compositions and methods of use

Method for identifying a hedgehog-mediated phosphorylation state dependent transcription factor

Multiple methods for measuring the COUP-TF system, including: a method to measure the level of COUP-TF by combining antibodies with biological samples and measuring the resultant antibody/COUP-TF complex; the binding of COUP-TF to promoters by combining biological samples with COUP-TF binding oligonucleotides and measuring the resultant complex or gene synthesis; and a method to measure COUP-TF inducable promoters by combining native COUP-TF with nuclear extracts of biological samples and measuring the resultant complexes. The methods when applied to human biological samples can detect diabetes due to COUP-TF or promoter defects. In addition to the methods for measuring the COUP-TF system and associated diseases, there are also the polyclonal and monoclonal antibodies necessary for the methods. These bind to at least one immunoreactive site on COUP-TF. Furthermore, there is a DNA clone containing the genetic coding regions of the COUP-TF protein.

Assays of coup transcription factor interactions in mammalian systems

The present invention provides a novel method of determining the antagonist and agonist activity of a compound for steroid hormone receptors. The present invention also provides a method of determining antagonist activity of a compound for a hormone receptor by inducing the conformational change in the receptor. In addition, the present invention provides a novel method of determining the level of agonist activity of a compound for steroid hormone receptors.

Method of identifying hormone antagonists and agonists

Growing community of inventors

Houston, TX, United States of America

Sophia Yang Tsai