Snow Brand Milk Products Co., Ltd.

Shun'ichi Dosako

Toshiaki Uchida

Yoshihiro Kawasaki

Naoki Yamamoto

Kaoru Sato

Hideki Nakashima

Wataru Motsuchi

Shigeaki Tanaka

This invention relates to inhibitors against viral infection and proliferation composed of peptides shown by below mentioned amino acid sequence (1) or (2). ##STR1## The inhibitors against viral infection and proliferation of the present invention can suppress the infection and proliferation of influenza virus or cytomegalo virus, and are useful for the prevention and treatment of diseases caused by these viruses.

Viral infection and proliferation inhibitors

Lactoperoxidase, secretory component and lactoferrin are separated in high purity from milk and related materials such as whey with a single cation exchange resin. After adsorption on the cation exchange resin, elution is carried out with an aqueous solution having an ionic strength and pH selected to elute each separately. Lactoperoxidase is eluted first, secretory component second and lactoferrin last. Each is obtained in a purity of about 80% or greater. The cation exchange resin can be a cross-linked polysaccharide, cellulose or an acrylamide resin having carboxyl, sulfonic acid or phosphoric acid functional groups which may be attached with a spacer. The separated lactoperoxidase, secretory component and lactoferrin are biologically active and can be used in pharmaceuticals, cosmetics, foods, drinks and feeds.

Separation of lactoperoxidase, secretory component and lactoferrin from

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Urawa, Japan

Shun'ichi Dosako