Bristol-myers Squibb Compnay

Other

Bristol-myers Company

Shreeram N Agharkar

Joseph B Bogardus

Uday S Gogate

Murray A Kaplan

Lawan Phusanti

Ismat Ullah

Richard G Corrao

Gururaj Bykadi

Edward J Bara

Mehdi Paborji

William P Coppola

Munir N Nassar

This invention relates to a stable, easy to constitute, injectable formulation of anticancer agent BMY-25067. More specifically, the present invention concerns a formulation of BMY-25067 obtained from lyophilizing a solution comprising up to 4 mg of BMY-25067 per mL of 65% t-butanol/water, further comprising about 2% PVP (K-12 or K-17), optionally comprising pharmaceutically acceptable carrier(s).

Stable injectable formulation of BMY-25067

A stabilized pharmaceutical composition containing paclitaxel, teniposide, camptothecin or other antineoplastic agent susceptible to degradation during storage is produced using a solvent system containing a low carboxylate anion content. The solvent system is a mixture of ethanol and a polyoxyethylated castor oil. The polyoxyethylated castor oil is treated with an acid or contacted with alumina to reduce the carboxylate anion content of the solvent. The low carboxylate anion content of the solvent provides extended shelf life and lower amounts of degradation by-products.

Stabilized pharmaceutical composition and stabilizing solvent

A stable solution of mitomycin C in propylene glycol or propylene glycol/water is disclosed. The solutions have an acceptable shelf-life of greater than 24 months at 4.degree. C. and can be injected directly or diluted with water or other aqueous parenteral vehicle for parenteral administration.

Stable solutions of mitomycin C

A solution of etoposide in dimethylisosorbide is disclosed. The solution is useful for filling gelatin capsules and may also be formulated into parenteral dosage forms.

Etoposide solutions

Stable, injectable, aqueous solutions of 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-[(substituted)alkoxy]benzamid e antiemetic agents are prepared by adding, as stabilizing agent, a pharmaceutically acceptable, water-miscible, hydroxylic organic solvent or water-soluble polyhydric alcohol or sugar which decreases the polarity of the solution.

Stable injectable antiemetic compositions

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Fayetteville, NY, United States of America

Shreeram N Agharkar